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Ember Root Home About Services Clinical Evidence Safety & Risks Access & Policy Contact Independent information resource Ibogaine Drug Treatment Ibogaine is a psychoactive indole alkaloid from Tabernanthe iboga being investigated as an experimental treatment for opioid use disorder and other conditions. It has drawn serious research interest—and serious safety concerns. The plain starting point: ibogaine is not FDA-approved for any indication in the United States, and it remains a Schedule I controlled substance. Its history as a psychoactive compound is summarized in the established overview of ibogaine , while the treatment question remains unsettled. Evidence, uncertainty, and safety belong in the same conversation. What it is—and is not An experimental compound, not an established treatment. Ibogaine is a naturally occurring psychoactive compound extracted from the root bark of the African shrub Tabernanthe iboga . The literature often focuses on one-dose, medically supervised protocols intended to interrupt withdrawal and craving, especially in opioid dependence. Research also extends to substance-use disorders, depression, anxiety, PTSD, traumatic brain injury, and military-veteran health. That breadth should not be mistaken for proof. A peer-reviewed safety review indexed by PubMed underscores why benefits and harms must be evaluated together. 18–36 hours is a commonly reported duration for a therapeutic session. 10–20 mg/kg is a commonly cited modern clinical dose range. Schedule I is ibogaine’s current status in the United States. Evidence in motion Why the conversation has changed. Ibogaine has moved from a fringe-psychedelic discussion into a visible policy, funding, and clinical-trial conversation. Texas committed $50 million for ibogaine research and has moved into a clinical-trial program. Federal attention has also increased, while researchers continue to examine where signal ends and certainty begins. Stanford-led work and other studies have

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